by Dr. Ken Kasza et al.

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Application in Advanced Laparoscopic Procedures

Medical procedures are becoming less invasive through the development of laparoscopic procedures assisted by robotic manipulations. Critical organs and various tissue masses must be protected through the course of these manipulations, which often cause damage that results in loss of organ function and life-threatening infection. Those complications could be reduced if targeted cooling could be administered quickly and effectively.

We have conduced exploratory research with NIH funding on use of slurry-induced protective cooling under minimally invasive laparoscopic surgery to protect kidneys during “blood vessel clamp-off”. As indicated in Figure 2 a swine kidney was successfully cooled by using a specially designed slurry delivery tip compatible with standard laparoscopic ports.

We have also developed a three-dimensional computer model using the ABAQUS code that can be used for predictions of kidney ice slurry cooling during laparoscopic surgery. Figure 3 shows model calculations of kidney cooling temperature following kidney blood vessel clamp-off and application of slurry at time = 0 and for time > 20 min. when the slurry was removed and the blood vessels were unclamped compared with data from the large-animal model experiments at UC. The image on the left shows the four positions in the kidney for the model calculations of temperature.

Medical Ice Slurry Coolants for Inducing Targeted-Organ/Tissue Protective Cooling
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